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Bottom right, RMSF values plotted on the GLP-1R structure bound to TT-OAD2 (transparent stick representation)

One of the most discussed next generation obesity treatments is Retatrutide, a triple agonist peptide currently being studied for its effects on weight reduction, appetite suppression and metabolic health

Furthermore, semaglutide attenuates the progression of chronic kidney disease and reduces cardiovascular death in patients with T2D and diabetic kidney disease (6), and slows eGFR decline and progression to end stage chronic kidney disease in patients with obesity and atherosclerotic cardiovascular disease (7)